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The general rule, for position of things in a linear sequence:  The final position is the most emphatic, the initial position is the second-most emphatic, and the middle position is the least emphatic.

In terms of sentence structure, this is why you shouldn’t end a sentence with a weakening word like “though” or “however” (unless you have a specific reason for wanting that particular kind of anticlimactic effect), and why you should arrange your main and subordinate clauses in such a way as to reserve the final position for your most important idea.

In terms of plot structure, it goes a long way toward explaining why the middle of the book is always the hardest part to write.